The ENA Profile test is a specialized blood test used to detect specific autoantibodies associated with autoimmune and connective tissue diseases. These conditions often present with vague symptoms such as joint pain, fatigue, skin rashes, or unexplained inflammation, making accurate diagnosis challenging without advanced laboratory testing. The ENA Profile helps doctors identify the underlying cause by detecting antibodies that attack the body’s own tissues.
In Pakistan, the ENA Profile test at Dr. Essa Laboratory and Diagnostic Centre is widely trusted for its accuracy, standardized testing methods, and reliable reporting. Dr. Essa Laboratory is recognized for maintaining high diagnostic standards, employing experienced laboratory staff, and utilizing modern equipment, which makes it a preferred choice for complex immunological tests.
If your doctor suspects conditions like lupus, Sjögren’s syndrome, scleroderma, or mixed connective tissue disease, the ENA Profile test plays a critical role in confirming the diagnosis and guiding treatment. In this detailed guide, you will learn everything about the ENA Profile test, including its purpose, preparation, procedure, normal values, interpretation, and the ENA Profile test price at Dr. Essa Laboratory, along with booking details in Pakistan.
What is ENA Profile?
The ENA Profile (Extractable Nuclear Antigen Profile) is a blood test that detects a group of specific autoantibodies directed against extractable nuclear antigens present in the cell nucleus. These autoantibodies are commonly associated with autoimmune connective tissue disorders.
The ENA Profile usually includes antibodies such as:
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Anti-Sm
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Anti-RNP
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Anti-SSA (Ro)
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Anti-SSB (La)
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Anti-Scl-70
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Anti-Jo-1
Doctors often recommend the ENA Profile when an ANA (Antinuclear Antibody) test comes back positive. While ANA indicates the presence of autoimmunity, the ENA Profile helps pinpoint the exact disease.
This test is commonly used in rheumatology, immunology, and internal medicine to support the diagnosis of autoimmune conditions and to differentiate between similar disorders with overlapping symptoms.
Why is the ENA Profile Important?
The ENA Profile is important because autoimmune diseases can be difficult to diagnose based on symptoms alone. Many of these conditions share similar signs, such as joint pain, muscle weakness, dry eyes, or skin changes. The ENA Profile provides clarity by identifying disease-specific antibodies.
Key reasons why the ENA Profile test matters:
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Helps confirm autoimmune and connective tissue diseases
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Assists in differentiating between similar conditions
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Supports early diagnosis, which improves treatment outcomes
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Guides doctors in choosing appropriate therapy
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Helps monitor disease progression in some cases
Without accurate antibody testing, autoimmune diseases may remain undiagnosed or misdiagnosed for years. The ENA Profile at Dr. Essa Laboratory offers dependable results that help doctors make informed clinical decisions.
When Should You Get an ENA Profile Test?
A doctor may advise an ENA Profile test in the following situations:
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Positive ANA test result
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Persistent joint pain or swelling
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Muscle weakness or stiffness
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Unexplained fatigue or fever
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Skin rashes, especially photosensitive rashes
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Dry eyes or dry mouth
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Raynaud’s phenomenon (cold fingers turning white or blue)
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Suspected lupus, Sjögren’s syndrome, or scleroderma
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Follow-up evaluation of a known autoimmune disease
The test is not usually done as a routine screening but is ordered when there is a strong clinical suspicion of autoimmune disease.
How to Prepare for ENA Profile?
Preparing for the ENA Profile test is simple and patient-friendly.
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Fasting: No fasting is usually required
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Medications: Inform your doctor about all medicines and supplements you are taking
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Hydration: Drink water to stay well hydrated
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Rest: No special rest or activity restriction is needed
Always follow your doctor’s instructions, especially if you are on immunosuppressive or steroid medications, as they may influence test results.
How is the ENA Profile Performed at Dr. Essa Laboratory?
The ENA Profile test at Dr. Essa Laboratory and Diagnostic Centre is performed using a blood sample.
Step-by-step process:
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A trained phlebotomist collects a small blood sample from a vein in your arm
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The procedure takes only a few minutes
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The sample is properly labeled and sent to the laboratory
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Advanced immunoassay techniques are used to detect ENA antibodies
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Strict quality control measures ensure accurate and reliable results
Dr. Essa Laboratory follows professional standards, ensuring patient privacy, hygienic sample handling, and precise reporting.
ENA Profile Report & Normal Values
The ENA Profile report shows whether specific antibodies are negative or positive. Normal values are generally reported as negative.
ENA Profile Normal Values Table
| Antibody Tested | Normal Result |
|---|---|
| Anti-Sm | Negative |
| Anti-RNP | Negative |
| Anti-SSA (Ro) | Negative |
| Anti-SSB (La) | Negative |
| Anti-Scl-70 | Negative |
| Anti-Jo-1 | Negative |
Understanding the Report
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Negative result: No detectable disease-specific autoantibodies
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Positive result: Suggests the presence of a specific autoimmune condition
Only a qualified doctor can interpret the results accurately in combination with symptoms and other tests.
Understanding Abnormal Results
Abnormal or positive ENA Profile results may indicate:
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Anti-Sm: Systemic lupus erythematosus (SLE)
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Anti-RNP: Mixed connective tissue disease
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Anti-SSA / Anti-SSB: Sjögren’s syndrome or lupus
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Anti-Scl-70: Systemic sclerosis (scleroderma)
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Anti-Jo-1: Polymyositis or dermatomyositis
A positive result does not always mean severe disease. Some people may have antibodies without active symptoms, which is why clinical correlation is essential.
Managing Autoimmune Health Naturally (Supportive Tips)
While medical treatment is essential, supportive lifestyle measures can help manage autoimmune conditions:
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Maintain a balanced, anti-inflammatory diet
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Get adequate sleep and manage stress
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Engage in gentle physical activity as advised by your doctor
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Avoid smoking and excessive caffeine
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Follow prescribed medications strictly
These steps support overall immune health but do not replace medical treatment.
ENA Profile Test Cost at Dr. Essa Laboratory
The ENA Profile test cost at Dr. Essa Laboratory is Rs. 6,280. This price reflects the complexity of the test and the advanced laboratory techniques involved. Patients can conveniently book the test online and visit the nearest Dr. Essa Laboratory branch for sample collection.
The Dr. Essa Laboratory ENA Profile price of Rs. 6,280 is competitive and aligned with quality diagnostic standards in Pakistan.
Dr. Essa Laboratory ENA Profile Price in Pakistan
The Dr. Essa Laboratory ENA Profile price in Pakistan is Rs. 6,280.
You can easily compare ENA Profile test costs in Pakistan, check Dr. Essa Laboratory test charges 2026, and book your test through All Lab Tests for a smooth and reliable experience.
Where to Book the ENA Profile Test in Pakistan
Looking for “ENA Profile test near me”?
You can:
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Compare ENA Profile cost in Pakistan
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View Dr. Essa Laboratory ENA Profile test fee 2026
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Choose the nearest Dr. Essa Laboratory branch
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Book your test online through All Lab Tests
This saves time and ensures transparent pricing with trusted diagnostic centers.
Book Your ENA Profile Test at Dr. Essa Laboratory
Book your ENA Profile test at Dr. Essa Laboratory today through All Lab Tests and get accurate, reliable results from a trusted diagnostic center in Pakistan.
Enjoy:
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Easy online booking
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Affordable and transparent pricing
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Professional sample collection
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Fast and reliable reports
Take control of your health with confidence – book your ENA Profile test now and get expert diagnostic care all in one place.
